Our Childhood Apraxia of Speech Research

  1. Alawadhi, A., Morgan, A. T., Mucha, B. E., Scheffer, I. E., & Myers, K. A. (2021). Self-limited focal epilepsy and childhood apraxia of speech with WAC pathogenic variants. European Journal of Paediatric Neurology, 30, 25-28.
  2. Chenausky, K. V., Brignell, A., Morgan, A., Gagné, D., Norton, A., Tager-Flusberg, H., ... & Green, J. R. (2020). Factor analysis of signs of childhood apraxia of speech. Journal of communication disorders, 87, 106033.
  3. Eising, E., Carrion-Castillo, A., Vino, A., Strand, E.A., Jakielski, K.J., Scerri, T.S., Hildebrand, M.S., Webster, R., Ma, A., Mazoyer, B., Frankcs, C., Bahlo, M., Scheffer, I.E., Morgan, A.T., Shriberg, L.D., & Fisher, S.E. (2019). A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development. Molecular Psychiatry, 24, 1065-1078.
  4. Fedorenko, E., Morgan, A., Murray, E., Cardinaux, A., Mei, C., Tager-Flusberg, H., ... & Kanwisher, N. (2016). A highly penetrant form of childhood apraxia of speech due to deletion of 16p11. 2. European Journal of Human Genetics, 24(2), 302-306.
  5. Frédérique J Liégeois, Samantha J Turner, Angela Mayes, Alexandra F Bonthrone, Amber Boys, Libby Smith, Bronwyn Parry-Fielder, Simone Mandelstam, Megan Spencer-Smith, Melanie Bahlo, Tom S Scerri, Michael S Hildebrand, Ingrid E Scheffer, Alan Connelly, Angela T Morgan, Dorsal language stream anomalies in an inherited speech disorder, Brain, Volume 142, Issue 4, April 2019, Pages 966–977, https://doi.org/10.1093/brain/awz018
  6. Hildebrand, M.S., Jackson, V.E., Scerri, T.S., Van Reyk, O., Coleman, M., Braden, R.O., Turner, S., Rigbye, K.A., Boys, A., Barton, S., Webster, R., Fahey, M., Saunders, K., Parry-Fielder, B., Paxton, G., Hayman, M., Coman, D., Goel, H., Baxter, A., Ma, A., Davis, N., Reilly, S., Delatycki, M., Liégeois, F.J., Connelly, A., Gecz, J., Fisher, S.E., Amor, D.J., Scheffer, I.E., Bahlo, M., Morgan, A.T. (2020). Severe childhood speech disorder: Gene discovery highlights transcriptional dysregulation. Neurology.
  7. Kaspi, A., Hildebrand, M. S., Jackson, V. E., Braden, R., Van Reyk, O., Howell, T., ... & Morgan, A. T. (2022). Genetic aetiologies for childhood speech disorder: novel pathways co-expressed during brain development. Molecular Psychiatry, 1-17.
  8. Khan, K., Zech, M., Morgan, A.T., Amor, D.J., Skorvanek, M., Khan, T.N., et al. (2019). Recessive variants in ZNF142 cause a complex neurodevelopmental disorder with intellectual disability, speech impairment, seizures, and dystonia. Genetics in Medicine, 21(11), 2532-2542.
  9. Liégeois, F. J., & Morgan, A. T. (2012). Neural bases of childhood speech disorders: lateralization and plasticity for speech functions during development. Neuroscience & Biobehavioral Reviews, 36(1), 439-458.
  10. Liégeois, F., Mayes, A. & Morgan, A. (2014) Neural Correlates of Developmental Speech and Language Disorders: Evidence from Neuroimaging. Curr Dev Disord Rep1, 215–227. https://doi.org/10.1007/s40474-014-0019-1
  11. Liegeois, F., Morgan, A.T., Connelly, A., & Vargha-Khadem, F. (2011). Endophenotypes of FOXP2: dysfunction within the human articulatory network. European Journal of Paediatric Neurology, 15(4), 283-288.
  12. Mei, C., Fedorenko, E., Amor, D. J., Boys, A., Hoeflin, C., Carew, P., ... & Morgan, A. T. (2018). Deep phenotyping of speech and language skills in individuals with 16p11. 2 deletion. European Journal of Human Genetics, 26(5), 676-686.
  13. Morgan, A.T., Amor, D.J., St John, M., Scheffer, I.E., Hildebrand, M.S. (2024). The genetic architecture of childhood speech disorder: a review. Molecular Psychiatry. 10.1038/s41380-024-02409-8
  14. Morgan A, Bonthrone A, Liégeois FJ. (2016) Brain basis of childhood speech and language disorders: are we closer to clinically meaningful MRI markers? Curr Opin Pediatr. Dec;28(6):725-730. doi: 10.1097/MOP.0000000000000420. PMID: 27662370.
  15. Morgan, A. T., & Vogel, A. P. (2009). A Cochrane review of treatment for childhood apraxia of speech. European journal of physical and rehabilitation medicine, 45(1), 103-110.
  16. Morgan, A. T., & Webster, R. (2018). Aetiology of childhood apraxia of speech: A clinical practice update for paediatricians. Journal of paediatrics and child health, 54(10), 1090-1095.
  17. Morgan, A. T., Murray, E., & Liegeois, F. J. (2018). Interventions for childhood apraxia of speech. Cochrane Database of Systematic Reviews, (5).
  18. Morgan, A., Braden, R., Wong, M. M., Colin, E., Amor, D., Liégeois, F., Srivastava, S., Vogel, A., Bizaoui, V., Ranguin, K., Fisher, S. E., & van Bon, B. W. (2021). Speech and language deficits are central to SETBP1 haploinsufficiency disorder. European Journal of Human Genetics, 29(8), 1216–1225. https://doi.org/10.1038/s41431-021-00894-x
  19. Morgan, A., Fisher, S.E., Scheffer, I., Hildebrand, M. (2016). FOXP2- Related Speech and Language Disorders. GeneReview
  20. Morgan, A., Haaften, L.v., van Hulst, K. et al.Early speech development in Koolen de Vries syndrome limited by oral praxis and hypotonia. Eur J Hum Genet 26, 75–84 (2018). https://doi.org/10.1038/s41431-017-0035-9
  21. Turner, S. J., Hildebrand, M. S., Block, S., Damiano, J., Fahey, M., Reilly, S., ... & Morgan, A. T. (2013). Small intragenic deletion in FOXP2 associated with childhood apraxia of speech and dysarthria. American journal of medical genetics Part A, 161(9), 2321-2326.
  22. Turner, S. J., Vogel, A. P., Parry-Fielder, B., Campbell, R., Scheffer, I. E., & Morgan, A. T. (2019). Looking to the future: Speech, language, and academic outcomes in an adolescent with childhood apraxia of speech. Folia Phoniatrica et Logopaedica, 71(5-6), 203-215.

 

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