Our Childhood Apraxia of Speech Research

  1. Alawadhi, A., Morgan, A. T., Mucha, B. E., Scheffer, I. E., & Myers, K. A. (2021). Self-limited focal epilepsy and childhood apraxia of speech with WAC pathogenic variants. European Journal of Paediatric Neurology, 30:25-28. doi: 10.1016/j.ejpn.2020.12.010.
  2. Atkinson C, Lee YQ, Lauretta ML, Jarmolowicz A, Amor DJ, Morgan AT. Parental attitudes and experiences in pursuing genetic testing for their child’s motor speech disorder. (2024). Eur J Hum Genet. Dec 9.  https://www.nature.com/articles/s41431-024-01755-z
  3. Chenausky, K. V., Brignell, A., Morgan, A., Gagné, D., Norton, A., Tager-Flusberg, H., ... & Green, J. R. (2020). Factor analysis of signs of childhood apraxia of speech. Journal of communication disorders, Sep-Oct;87:106033. doi: 10.1016/j.jcomdis.2020.106033.
  4. Eising, E., Carrion-Castillo, A., Vino, A., Strand, E.A., Jakielski, K.J., Scerri, T.S., Hildebrand, M.S., Webster, R., Ma, A., Mazoyer, B., Frankcs, C., Bahlo, M., Scheffer, I.E., Morgan, A.T., Shriberg, L.D., & Fisher, S.E. (2019). A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development. Molecular Psychiatry, 24(7):1065-1078. doi: 10.1038/s41380-018-0020-x.
  5. Fedorenko, E., Morgan, A., Murray, E., Cardinaux, A., Mei, C., Tager-Flusberg, H., ... & Kanwisher, N. (2016). A highly penetrant form of childhood apraxia of speech due to deletion of 16p11. 2. European Journal of Human Genetics, 24(2):302-306.
  6. Liégeois, F.J., Turner, S.J., Mayes, A., Bonthrone, A.F., Boys, A., Smith, L., Parry-Fielder, B., Mandelstam, S., Spencer-Smith, M., Bahlo, M., Scerri, T.S., Hildebrand, M.S., Scheffer, I.S., Connelly, A., Morgan, A.T. (2019). Dorsal language stream anomalies in an inherited speech disorder, Brain, 142(4):966-977. doi: 10.1093/brain/awz018. 
  7. Hildebrand, M.S., Jackson, V.E., Scerri, T.S., Van Reyk, O., Coleman, M., Braden, R.O., Turner, S., Rigbye, K.A., Boys, A., Barton, S., Webster, R., Fahey, M., Saunders, K., Parry-Fielder, B., Paxton, G., Hayman, M., Coman, D., Goel, H., Baxter, A., Ma, A., Davis, N., Reilly, S., Delatycki, M., Liégeois, F.J., Connelly, A., Gecz, J., Fisher, S.E., Amor, D.J., Scheffer, I.E., Bahlo, M., Morgan, A.T. (2020). Severe childhood speech disorder: Gene discovery highlights transcriptional dysregulation. Neurology, 94(20):e2148-e2167. doi: 10.1212/WNL.0000000000009441.
  8. Kaspi, A., Hildebrand, M. S., Jackson, V. E., Braden, R., Van Reyk, O., Howell, T., ... & Morgan, A. T. (2023). Genetic aetiologies for childhood speech disorder: novel pathways co-expressed during brain development. Molecular Psychiatry, 28(4):1647-1663
  9. Khan, K., Zech, M., Morgan, A.T., Amor, D.J., Skorvanek, M., Khan, T.N., et al. (2019). Recessive variants in ZNF142 cause a complex neurodevelopmental disorder with intellectual disability, speech impairment, seizures, and dystonia. Genetics in Medicine, 21(11):2532-2542.
  10. Liégeois, F. J., & Morgan, A. T. (2012). Neural bases of childhood speech disorders: lateralization and plasticity for speech functions during development. Neuroscience & Biobehavioral Reviews, 36(1):439-458. 
  11. Liégeois, F., Mayes, A. & Morgan, A. (2014). Neural Correlates of Developmental Speech and Language Disorders: Evidence from Neuroimaging. Curr Dev Disord Rep, 1(3):215-227. 
  12. Liegeois, F., Morgan, A.T., Connelly, A., & Vargha-Khadem, F. (2011). Endophenotypes of FOXP2: dysfunction within the human articulatory network. European Journal of Paediatric Neurology, 15(4): 283-288.
  13. Mei, C., Fedorenko, E., Amor, D. J., Boys, A., Hoeflin, C., Carew, P., ... & Morgan, A. T. (2018). Deep phenotyping of speech and language skills in individuals with 16p11. 2 deletion. European Journal of Human Genetics, 26(5):676-686.
  14. Morgan, A.T., Amor, D.J., St John, M., Scheffer, I.E., Hildebrand, M.S. (2024). The genetic architecture of childhood speech disorder: a review. Molecular Psychiatry, 29(5):1281-1292. 10.1038/s41380-024-02409-8
  15. Morgan A, Bonthrone A, Liégeois FJ. (2016). Brain basis of childhood speech and language disorders: are we closer to clinically meaningful MRI markers? Curr Opin Pediatr. Dec;28(6):725-730. doi: 10.1097/MOP.0000000000000420.
  16. Morgan, A. T., & Vogel, A. P. (2009). A Cochrane review of treatment for childhood apraxia of speech. European journal of physical and rehabilitation medicine, 45(1):103-110.
  17. Morgan, A. T., & Webster, R. (2018). Aetiology of childhood apraxia of speech: A clinical practice update for paediatricians. Journal of paediatrics and child health, 54(10):1090-1095.
  18. Morgan, A. T., Murray, E., & Liegeois, F. J. (2018). Interventions for childhood apraxia of speech. Cochrane Database of Systematic Reviews, 30;5(5):CD006278.
  19. Morgan, A., Braden, R., Wong, M. M., Colin, E., Amor, D., Liégeois, F., Srivastava, S., Vogel, A., Bizaoui, V., Ranguin, K., Fisher, S. E., & van Bon, B. W. (2021). Speech and language deficits are central to SETBP1 haploinsufficiency disorder. European Journal of Human Genetics, 29(8), 1216–1225. https://doi.org/10.1038/s41431-021-00894-x
  20. Morgan, A., Fisher, S.E., Scheffer, I., Hildebrand, M. (2016). FOXP2-Related Speech and Language Disorders. 2016 Jun 23 [updated 2023 Jan 26]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025.
  21. Morgan, A., Haaften, L.v., van Hulst, K. et al. (2018). Early speech development in Koolen de Vries syndrome limited by oral praxis and hypotonia. Eur J Hum Genet, 26(1):75-84. https://doi.org/10.1038/s41431-017-0035-9
  22. Turner, S. J., Hildebrand, M. S., Block, S., Damiano, J., Fahey, M., Reilly, S., ... & Morgan, A. T. (2013). Small intragenic deletion in FOXP2 associated with childhood apraxia of speech and dysarthria. American journal of medical genetics Part A, 161A(9):2321-2326. 
  23. Turner, S. J., Vogel, A. P., Parry-Fielder, B., Campbell, R., Scheffer, I. E., & Morgan, A. T. (2019). Looking to the future: Speech, language, and academic outcomes in an adolescent with childhood apraxia of speech. Folia Phoniatrica et Logopaedica, 71(5-6):203-215.

 

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